This comfort cross depicts some unique details related to St. Padre Pio. 
Padre Pio is often quotes as saying "Pray, Hope and Don't Worry"
A popular prayer associated with Padre Pio starts each section with "Stay with me, Lord" 
The dark area is the section of the cross that would be in contact with the right hand and is a patterned to represent his fingerless gloves. 
Central to the cross is a spot of deep red located where the stigmatic wound would be.